Participate in a Study

Studies Currently Enrolling at Our Center:

Misophonia Phenotyping Study

Do you belong to one of these groups:

-Extraordinarily bothered by certain sounds such as chewing, finger-tapping, etc.

-Tend to feel very anxious a lot of the time.

-Generally upbeat with no mental health problems.

We are looking for participants between 18 to 65 years old for our study on Misophonia, a condition in which people are extraordinarily bothered by certain kinds of sounds such as people eating or repetitive tapping.

For more information, please go here or email psychcmer@dm.duke.edu.

Pro00102579

Brain Stimulation and Emotion Regulation Study for Misophonia

Duke IRB# Pro00103683

Thank you for your interest in our study! If you would like to see if you may be eligible, please click here or read below for more information.

You might be eligible for this study if you:

• Are between 18-55 years old
• Experience misophonic distress or experience emotional dysregulation

Here are some further details about the study that may interest you:

This is a study in which we plan to disentangle Misophonia from emotional dysregulation and find the optimal neural target for Misophonia interventions. The study involves 3-4 visits that are 3-4 hours long. Note: The first visit can be done remotely. One visit will involve an MRI scan and one will involve neurostimulation. You will be paid depending on your time and participation in different parts of the study. You may have to wait until the end of the study to be paid.

Here’s how the process goes:
Once you complete the online survey by clicking this link, you will be contacted by phone by one of our study staff. If you are eligible for the study, you will have 1-2 assessment appointment(s). At your first assessment visit (which may be completed remotely), you will receive a full description of the study and choose whether or not you would like to consent to participate. If you do agree to participate, you will fill out questionnaires and speak with an interviewer. If the study is a good fit, you will then be asked to listen to aversive sounds and rate how distressing they are to you at an in-person visit while we measure your physiological arousal. This assessment day will last between 1 and 4 hours. The interviewer will ask you about many aspects of your life, including how you cope with stress, ways in which you tend to think about yourself, and how you get along with others.

Based on that interview, we’ll make the final decision about whether or not this study is a good fit for you. If you are not eligible for the study, you will receive $20 plus a parking pass or bus pass to cover your transportation, if applicable. If it is a good fit, we will ask a few more interview questions and give you a packet of self-reports to complete online.

You will then participate in a brain imaging session. During the brain imaging session, you will be asked to think differently about the different sound presentations you experience, and rate and modulate how intensely you feel when hearing them. Next, you will be asked to return to the research office for the neurostimulation procedure. We will then teach you how to think differently when exposed to distressing sounds so it’s easier to calm down and to feel negative emotions less intensely. We will then identify the dose of neurostimulation that is safe for you using a standardized procedure, and will expose you to different types of repetitive brain stimulation. You will hear different sounds via headphones and will be prompted to use cognitive restructuring to change your emotional experience while concurrently receiving different types of neurostimulation. We will then ask you to complete a packet of questionnaires and an exit interview. If you are eligible for the study, you will be paid between $75 and $250, depending on your participation in different parts of the study. You may have to wait until the end of the study to get paid.

If you choose not to answer any questions you do not wish to answer, this will not affect your access to current or future health care at Duke. Your research data (answers to the online survey questions) will not be stored or be connected to any of your Duke University Health Care information. We will keep the answers to all of these screening questions as part of our research. We will destroy all identifying information such as your name and phone number at the end of the study. Only your answers to the questions, without your identifying data, will be used for research studies. This data will be kept indefinitely.

Click here to begin the online survey for the study.

Note: If you would prefer to do these questions over the phone with one of our study staff, you may contact us directly at (919) 684-6714. If you have any questions about participating in this study, please contact Judit Wright.

To read about additional planned Misophonia research studies, visit Upcoming Studies.

*Additionally, if you would like to be added to our growing list of people who are interested in hearing more about our program as well as future research opportunities please email us.

Studies Currently Enrolling at Collaborating Sites Outside Duke:

Helping Emotions and Providing Auditory Relief (U-HEAR) - University of Miami (Coral Gables, FL)

If someone is really sensitive to certain noises and sounds, they might have Misophonia. U-HEAR is a study created to find out what helps kids and teens with Misophonia. When kids and teens with Misophonia hear these sounds, they can feel very angry, annoyed, or feel another strong emotion. Then, they usually feel like they have to get away from the sound. They might leave the room, put their hands over their ears, put headphones on, or get really angry.

The kinds of sounds some kids and teens say bother them include: chewing, swallowing, breathing, sniffing, lip smacking, clock ticking, or pen clicking (and many others).

This study is for kids and teens living anywhere in the state of Florida between the ages of 8 and 16 who are struggling with these symptoms. The first step is a phone call where we will ask questions to find out if this study is a good fit for you or your child. If it is a good fit, the next step is to complete an interview and surveys (Note: With the current COVID situation, telehealth treatment visits are available through the University of Miami or The University of South Florida). We will ask questions that will help us figure out whether you (or your child) would be a good participant for our study. Participants will get ten free treatment sessions to help them deal with these annoying sounds. Each session will last one hour and happen once a week. 

To find out if your child is eligible for the study, contact us at anxietylab@psy.miami.edu, or at 305-284-9852 ext 1. You can find also find more information for the study here: U-HEAR at Univ. of Miami