We have several funded studies being prepared for recruitment:
(1) Phenotyping Study of Misophonia
Exciting new research on Misophonia validates what our patients and family members tell us: Misophonia is real, and can be extremely impairing and distressing. Unfortunately, very little is known about the nature of Misophonia, or its causes and correlates, compared to other known clinical phenomena. This means that we truly don't know the boundaries around what Misophonia is, and what it is not. Until we better understand what it is, it will be difficult to obtain funding from the NIH or other funding agencies to develop and test treatments for Misophonia.
In this study, we will collect a range of measures related to the causes and correlates of Misophonia. For example, we will use gold standard psychiatric interviews to examine whether Misophonia is differentially related to any specific psychiatric disorders. We will use laboratory psychophysiological methods to differentiate Misophonia and other clinical conditions on measures related to emotional reactivity. And, importantly, we will use ecological momentary assessment methods to characterize the temporal dynamics of Misophonia symptoms and difficulties regulating emotions over time compared to other clinical conditions.
(2) Identifying the Optimal Neural Target for Misophonia Interventions
In order to develop treatments for Misophonia, it is important to gain a better understanding about what is happening in the brain when people with Misophonia (and those without) are triggered by misophonic and non-misophonic cues. In this study (PI: Neacsiu) funded by the REAM Foundation and supported by CMER, the primary aim is to disentangle the brain circuitry dysfunction in Misophonia when compared to highly emotional dysregulated adults without Misophonia. A secondary aim is to examine changes in misophonic distress and regulation when applying inhibitory, excitatory, or sham repetitive transcranial magnetic stimulation (rTMS) over key neural networks.